Healthcare Sector Performance: The overall health of the healthcare industry, including pharmaceutical, biotech, and medical device companies, significantly impacts CURE.US as it tracks an index focused on innovative healthcare.

Index Composition: Changes to the underlying index's constituents, such as the addition or removal of companies, directly affect the ETF's price.

Interest Rates: Interest rate hikes may make bonds more attractive relative to stocks, potentially leading to capital outflow from CURE.US.

Market Sentiment: General investor optimism or pessimism towards growth stocks and the healthcare sector will influence demand and thus the ETF's price.

Economic Indicators: Macroeconomic data like GDP growth, inflation, and unemployment figures can affect corporate earnings and investor risk appetite, impacting CURE.US.

Currency Fluctuations: Changes in the exchange rate between the US dollar and other currencies, especially if the fund holds international assets, can impact the ETF’s price.