Drug Pipeline Success: Positive clinical trial results for new drugs boost investor confidence, increasing demand and price. Failed trials can have the opposite effect.

Regulatory Approvals: Approval of key drugs by regulatory bodies like the FDA or EMA significantly increases potential revenue and thus the stock price.

Market Competition: The presence of competing drugs, especially generics, can impact AstraZeneca's market share and profitability, affecting the stock price.

Economic Conditions: General economic upturns can increase healthcare spending, benefiting pharmaceutical companies like AstraZeneca. Downturns can have a negative impact.

Patent Expirations: Loss of patent protection for key drugs can lead to generic competition and lower sales, negatively impacting the stock price.

Dividend Policy: AstraZeneca's dividend payouts and dividend yield affect investor attractiveness and can influence the stock price.

Global Health Crises: Pandemics or major disease outbreaks can create increased demand for AstraZeneca's products and influence the stock price positively or negatively.

Company News and Announcements: Company-specific news such as earnings reports, mergers, acquisitions, and strategic partnerships greatly affect stock price.